Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects (Cell Chemical Biology)

Ye, Zhang et al. identify frenolicin B as a potent and selective inhibitor of Prx1 and Grx3, leading to generation of ROS and subsequent repression of mTORC1/4E-BP1-mediated translational control of tumor growth with the potential to be developed into a new class of anticancer agents.