Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets (Molecular Cell)

Mengwasser et al. perform several genetic screens to systematically identify genes and pathways required for BRCA2-mutant cell survival. They find that BRCA2-mutant cells rely on base excision repair, ATR signaling, splicing, and MMEJ. APEX2 and FEN1, involved in replication-associated BER and MMEJ, respectively, are potential targets in BRCA-mutant tumors.