Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase (Cell Chemical Biology)

König et al. identified leukotriene A4 hydrolase (LTA4H) in human leukocytes as a molecular target of gliotoxin from Aspergillus fumigatus. Under reducing conditions, gliotoxin inhibits leukotriene A4 hydrolase activity leading to suppression of chemotactic leukotriene B4 biosynthesis and neutrophil infiltration, which may underlie the neutrophil-compromising properties of this fungal toxin.