Entropy, Vol. 21, Pages 168: Dense U-net Based on Patch-Based Learning for Retinal Vessel Segmentation (Entropy)

Various retinal vessel segmentation methods based on convolutional neural networks were proposed recently, and Dense U-net as a new semantic segmentation network was successfully applied to scene segmentation. Retinal vessel is tiny, and the features of retinal vessel can be learned effectively by the patch-based learning strategy. In this study, we proposed a new retinal vessel segmentation framework based on Dense U-net and the patch-based learning strategy. In the process of training, training patches were obtained by random extraction strategy, Dense U-net was adopted as a training network, and random transformation was used as a data augmentation strategy. In the process of testing, test images were divided into image patches, test patches were predicted by training model, and the segmentation result can be reconstructed by overlapping-patches sequential reconstruction strategy. This proposed method was applied to public datasets DRIVE and STARE, and retinal vessel segmentation was performed. Sensitivity (Se), specificity (Sp), accuracy (Acc), and area under each curve (AUC) were adopted as evaluation metrics to verify the effectiveness of proposed method. Compared with state-of-the-art methods including the unsupervised, supervised, and convolutional neural network (CNN) methods, the result demonstrated that our approach is competitive in these evaluation metrics. This method can obtain a better segmentation result than specialists, and has clinical application value.