Aqueous olefin metathesis: recent developments and applications (Beilstein Journal of Organic Chemistry)

Abstract Olefin metathesis is one of the most powerful C–C double-bond-forming reactions. Metathesis reactions have had a tremendous impact in organic synthesis, enabling a variety of applications in polymer chemistry, drug discovery and chemical biology. Although challenging, the possibility to perform aqueous metatheses has become an attractive alternative, not only because water is a more sustainable medium, but also to exploit biocompatible conditions. This review focuses on the progress made in aqueous olefin metatheses and their applications in chemical biology. Beilstein J. Org. Chem. 2019, 15, 445–468. doi:10.3762/bjoc.15.39