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RSS FeedsMolecules, Vol. 24, Pages 687: Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract (Molecules)

 
 

17 february 2019 02:01:28

 
Molecules, Vol. 24, Pages 687: Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract (Molecules)
 




Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer’s disease (AD) activity by inhibiting amyloid β peptide (Aβ) aggregation and deposition. However, recent studies considered that the phenylethanoid glycosides may be metabolized by intestinal bacteria, because all analysis results showed that the bioavailability of phenylethanoid glycosides is extremely low. In this study we demonstrate how iron chelation plays a crucial role in the Aβ aggregation and deposition inhibition mechanism of phenylethanoid glycosides of CTE. In addition, we further proved phenylethanoid glycosides (1–3) could reach brain. Active CTE component and action mechanism confirmation will be a great help for product quality control and bioavailability studies in the future. At the same time, we provide a new analysis method useful in determining phenylethanoid glycosides (1–3) in plants, foods, blood, and tissues for chemical fingerprint and pharmacokinetic research.


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38 viewsCategory: Biochemistry, Chemistry, Molecular Biology
 
Molecules, Vol. 24, Pages 689: A Chemiluminescent Method for the Detection of H2O2 and Glucose Based on Intrinsic Peroxidase-Like Activity of WS2 Quantum Dots (Molecules)
Molecules, Vol. 24, Pages 686: Optimization of the Extraction Process to Obtain a Colorant Ingredient from Leaves of Ocimum basilicum var. purpurascens (Molecules)
 
 
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