Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme (Cell Reports)

Cliffe et al. show that the proteasome holoenzyme can fragment fibrils assembled from tau and ?-synuclein, both of which are associated with neurodegenerative disease. The fragmented aggregate species are structurally distinct from fibrils and more toxic than fibrils when added to cultured cells.