The present paper presents a study of biomass waste to energy conversion using gasification and internal combustion engine for power generation. The biomass waste analyzed is the most produced on Italian soil, chosen for suitable properties in the gasification process. Good quality syngas with up to 16.1% CO–4.3% CH4–23.1% H2 can be produced. The syngas lower heating value may vary from 1.86 MJ/ Nm3 to 4.5 MJ/Nm3 in the gasification with air and from 5.2 MJ/ Nm3 to 7.5 MJ/Nm3 in the gasification with steam. The cold gas efficiency may vary from 16% to 41% in the gasification with air and from 37% to 60% in the gasification with steam, depending on the different biomass waste utilized in the process and the different operating conditions. Based on the sensitivity studies carried out in the paper and paying attention to the cold gas efficiency and to the LHV, we have selected the best configuration process for the best syngas composition to feed the internal combustion engine. The influence of syngas fuel properties on the engine is studied through the electrical efficiency and the cogeneration efficiency.