A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis (Developmental Cell)

Mukherjee et al. demonstrate that cells are able to detect the magnitude of the tension that is built up across the centromeric regions of chromosomes at metaphase, and that cells respond to these changes to prevent chromosome mis-segregation in mitosis. Tension sensing thus underlies a fundamental mechanochemical mitotic safety mechanism.