Inheritance of a Phenotypically Neutral Epimutation Evokes Gene Silencing in Later Generations (Molecular Cell)

Duempelmann et al. describe an H3K9me3 and siRNA-dependent epimutation, which is installed during gene silencing and inherited across generations, even upon reactivation of the silenced gene. Yet silencing is reinstated in later generations if Paf1C is impaired, revealing H3K9me3 as a stable epigenetic mark that is not repressive per se.