Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance (Cell Host & Microbe)

Mutations in members of the KDM5 gene family are found in intellectual disability and autism spectrum disorder patients. Chen et al. discovered that KDM5-microbiota interactions contribute to animal social behavior. Drosophila deficient in kdm5 display gut dysbiosis, abnormal social behavior, and aberrant immune activation, which Lactobacillus plantarum administration can improve.