Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord (Cell Reports)

In order to cross the midline in the developing spinal cord, commissural axons must prevent premature responses to the midline repellant Slit. Here Gorla et al. define a key role for the Ndfip adaptor proteins in preventing the surface expression of the Robo1 receptor prior to midline crossing.