Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16 (Cell Reports)

Adipose Pin1 expression increases in obese mice. Pin1 associates with PRDM16 and promotes its degradation, resulting in the downregulation of UCP-1. Pin1 KO mice are resistant to obesity development and cold exposure-induced hypothermia. Thus, Pin1 is a negative regulator of thermogenesis and could be a target of obesity.