Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability (Molecular Cell)

V(D)J recombination errors have long been associated with chromosome alterations in lymphoid cancers. Here, Kirkham et al. describe an unexpected reaction where the recombination by-product complexes with the RAG recombinase to trigger DNA breaks throughout the genome. Notably, these breaks co-localize with those found in acute lymphoblastic leukemia.