The principle of maximum entropy (POME) has been used for a variety of applications in hydrology, however it has not been used in confidence interval estimation. Therefore, the POME was employed for confidence interval estimation for precipitation quantiles in this study. The gamma, Pearson type 3 (P3), and extreme value type 1 (EV1) distributions were used to fit the observation series. The asymptotic variances and confidence intervals of gamma, P3, and EV1 quantiles were then calculated based on POME. Monte Carlo simulation experiments were performed to evaluate the performance of the POME method and to compare with widely used methods of moments (MOM) and the maximum likelihood (ML) method. Finally, the confidence intervals T-year design precipitations were calculated using the POME for the three distributions and compared with those of MOM and ML. Results show that the POME is superior to MOM and ML in reducing the uncertainty of quantile estimators.