Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut (Cell Host & Microbe)

E. coli Nissle is a probiotic and chassis for engineered biotherapies, but its adaptive behavior in the gut is unclear. Crook et al. report host-mediated selective pressures modulating carbohydrate utilization and metabolism of E. coli Nissle. This in-host evolution also promotes probiotic survival by enabling effective stress responses during colonization.