Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver (Cell Metabolism)

Cappel et al. report that, in the liver, pyruvate carboxylase (PC) maintains TCA cycle intermediates, and that its loss is insufficiently compensated by alternative pathways. Hence, PC flux is essential for TCA-cycle-dependent biosynthesis, including gluconeogenesis, and has additional roles in maintaining substrate oxidation, ureagenesis, redox state, and antioxidant capacity.