Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion (Developmental Cell)

Rho et al. show a role for the small GTPase Rap1b in hematopoietic stem cell development in zebrafish. Rap1b promotes Notch-signal-mediated specification of posterior lateral plate mesoderm cells by inducing their adhesion to Notch-ligand-expressing somitic cells through integrin-?1-mediated adhesion to fibronectin localized at the somite boundary.