Intrinsically Disordered Protein TEX264 Mediates ER-phagy (Molecular Cell)

Macroautophagy can selectively recognize and degrade organelles such as the ER. Chino et al. identified TEX264 as a receptor for autophagic degradation of the ER (ER-phagy). A long intrinsically disordered region in TEX264 is required for its ER-phagy receptor function to bridge the gap between the ER and autophagosomes.