More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila (Cell Reports)

Dudzic et al. investigate the regulation of the melanization response in D. melanogaster with compound mutants of serine proteases. They find two distinct melanization pathways and a connection between melanization and the Toll pathway. Additionally, two related serine proteases, Hayan and Persephone, regulate the Toll pathway downstream of pattern-recognition receptors.