Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants (Molecular Cell)

The transcriptional activity of the tumor suppressor p53, which is essential to eliminate lethally damaged and oncogenic transformed cells, must be timed and balanced closely to prevent untimely induction of cell death. Boysen et al. show that Hsp70 and Hsp90 regulate p53`s conformation and DNA binding activity in opposing directions.