Thalamic Drive of Cortical Parvalbumin-Positive Interneurons during Down States in Anesthetized Mice (Current Biology)

Using a combination of electrophysiology, local pharmacology, and cell-specific optogenetic perturbations, Zucca et al. provide evidence that spontaneous thalamic activity inhibits cortex during down states through the suprathreshold activation of PV-positive interneurons.