Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein (Cell Chemical Biology)

Activating the ATF6 arm of the unfolded protein response selectively reduces the secretion and subsequent toxic aggregation of destabilized amyloidogenic light chains. Plate et al. use a quantitative proteomics platform to identify specific ATF6-regulated ER proteostasis factors responsible for regulating the secretion of an amyloidogenic light chain from mammalian cells.