Withdrawal: BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. [Withdrawals/Retractions] (Journal of Biological Chemistry)

VOLUME 277 (2002) PAGES 33422-33430This article has been withdrawn by Ying Yan and Kenneth H. Cowan. John P. Haas, Min Kim, and Magdalene K. Sgagias could not be reached. The first author identified some issues and brought them to the attention of the Journal. Subsequently, some issues were also noted in the article by the Journal. After careful analysis of all of the original data used for preparing the figures in the publication, the following errors were identified: The Actin immunoblot in the original Fig. 1A (identified from MCF-7) was used in the immunoblot for Fig. 6C (ERK1/2, lanes 3-4). In Fig. 2B (left panel, MCF7 cells), the Actin immunoblots for Ad.Control and Ad.BRCA1 were incorrect. The authors state that the Actin immunoblot for Ad.Control and Ad.BRCA1-infected MCF7 cells in Fig. 2B should have used the same Actin immunoblot depicted in Fig. 3 for MCF-7 cells infected with Ad.Control and Ad.BRCA1 as the results shown in Fig. 2B and Fig. 3 used the same set of lysates that were also probed for PARP (Fig. 2B) and Fas-L and Fas (Fig. 3). The JNK immunoblot in Fig. 4 (MCF-7) was reused as the Actin immunoblot in Fig. 4 (right panel) and the Actin immunoblot in Fig. 5E. The authors state that the top label for Fig. 7 (left panel) was incorrect and should have used the same top label shown in Fig. 5C. Both Figs. 5C and 7 (left panel) depict results obtained from the same MCF7 cell lysates infected with...