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RSS FeedsElevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs (Neuron)

 
 

21 may 2019 02:02:37

 
Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs (Neuron)
 


Zhang et al. (2019) find that amacrine cell hyperactivation after RGC axotomy prevents IGF1 responsiveness. Blocking amacrine cell synaptic activity potentiates IGF1-mediated axon regeneration by maintaining IGF1R localization to primary cilia, a localization that is normally lost in injured RGCs.


 
65 viewsCategory: Neurology
 
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Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment (Neuron)
 
 
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