Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons (Cell Reports)

Aras et al. provide in vivo evidence that tissue responsiveness to insulin varies in a diurnal fashion. In skeletal muscle, the authors show that photic inputs entrain diurnal changes in clock genes expression and insulin sensitivity via SIRT1 in neurons within the hypothalamic ventromedial nucleus.