Microbiology
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30 may 2019 21:03:19 |
| Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins (Cell Host & Microbe) |
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Tweet CRISPR-Cas12a protects bacteria from bacteriophages but is counteracted by inhibitors. Zhang et al. report cryo-EM structures of Cas12a bound to anti-CRISPR proteins. AcrVA1 binds to Cas12a by mimicking the protospacer-adjacent motif (PAM) of a target DNA and cleaves crRNA to inactivate Cas12a. AcrVA4 prevents conformational changes required for Cas12a activation. |
| 109 viewsCategory: Cell Biology, Immunology, Microbiology |
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