IL-10-Dependent Crosstalk between Murine Marginal Zone B Cells, Macrophages, and CD8?+ Dendritic Cells Promotes Listeria monocytogenes Infection (Immunity)

Splenic dendritic cells (DCs), IL-10, and marginal zone (MZ) B cells each promote Listeria monocytogenes infection. Liu et al. show that these paradoxical responses are linked. IL-10 production from MZ B cells enhances the intracellular Listeria burden in DCs by inhibiting bacterial killing in MZ metallophilic macrophages. This crosstalk in the MZ promotes CD8+ T cell activation but also Listeria infection.