EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis (Developmental Cell)

Macropinocytosis has emerged as an important protein-scavenging pathway that supports tumor cell fitness in a variety of oncopathological settings. Lee et al. provide a mechanistic understanding of how nutritional status can modulate this endocytic pathway in PDAC tumors, showing that glutamine-deprivation-induced potentiation of EGFR-Pak signaling regulates inducible macropinocytosis.