Molecules, Vol. 24, Pages 2565: Enantioselective Synthesis of Chromanones Bearing an ?,?-Disubstituted ?-Amino Acid Moiety via Decarboxylative Michael Reaction (Molecules)

In this manuscript, a novel, decarboxylative Michael reaction between α-substituted azlactones and chromone-3-carboxylic acids is described. The reaction proceeds in a sequence Michael addition followed by decarboxylative deprotonation, and it results in the formation of chromanones bearing an azlactone structural unit. The possibility of transforming an azlactone moiety into a protected α,α-disubstituted α-amino acid derivative is also demonstrated.