A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells (Cell Reports)

Cultures of haploid animal cell lines become progressively enriched in diploid cells. By conducting a chemical screen in HAP1 cells, Olbrich et al. identify compounds that facilitate the maintenance of haploid cells and a general strategy to select for cells with lower ploidy in mixed cultures of mammalian cells.