Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates ?-Secretase by Upregulating C/EBP? in Alzheimer`s Disease (Cell Reports)

Deficient BDNF/TrkB activity underlies AD pathogenesis. Wang et al. report that deprivation of BDNF/TrkB increases inflammatory cytokines and activates the JAK2/STAT3 pathway, resulting in the upregulation of C/EBP?/AEP signaling. Reduction of BDNF is inversely coupled with the aforementioned pathway in AD brains. Inhibition of JAK2/STAT3/C/EBP?/AEP prevents BDNF-depletion-mediated pathology.