Salmonella Coiled-Coil- and TIR-Containing TcpS Evades the Innate Immune System and Subdues Inflammation (Cell Reports)

Xiong et al. show that Salmonella subverts host TLR signaling by delivering a protein containing a TIR domain and a coiled-coil domain, TcpS. Immune evasion by TcpS supports early bacterial infection, which enables late-stage virulence and inflammation storm. TcpS-derived peptides reduce LPS-elicited systemic inflammation and are protective against influenza challenge in mice.