A Cellular Insulator against CLE45 Peptide Signaling (Current Biology)

This study by Breda et al. reveals a novel mechanism in the quantitative modulation of CLE peptide signaling. The authors demonstrate that the Arabidopsis protein OPS promotes root protophloem differentiation by antagonizing autocrine CLE45 peptide signaling, through direct interference with the CLE45 signaling components BAM3 and CLV2|CRN.