Characterizing Conduction Channels in Post-infarction Patients Using a Personalized Virtual Heart (Biophysical Journal)

Patients with myocardial infarction have an abundance of conduction channels (CC), however only a small subset of these CCs sustain ventricular tachycardia (VT). Identifying these critical CCs (CCCs) in the clinic, so that they can be targeted by ablation remains a significant challenge. The objective of this study is to use a personalized virtual-heart approach to conduct a 3D assessment of CCCs sustaining VTs of different morphologies in these patients, to investigate their 3D structural features, and to determine the optimal ablation strategy for each VT.