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RSS FeedsMechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease (Structure)

 
 

22 august 2019 17:02:41

 
Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease (Structure)
 


The 3.5-Å cryo-EM structure of the filament formed by the type II restriction endonuclease SgrAI bound to DNA described in Polley et al. reveals the relevance of indirect readout for enzyme activity and a mechanism for filament-induced activation of DNA cleavage.


 
158 viewsCategory: Biochemistry
 
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