Probing Exchange Units for Combining Iterative and Linear Fungal Nonribosomal Peptide Synthetases (Cell Chemical Biology)

Fungal iterative cyclodepsipeptide synthetases are combinable with exchange units from fungal linear assembly lines while respecting the specificities of the C domains at the artificial interfaces. Swapping can be performed in the T-C and C-A domain linker regions, while the C domains should be left intact.