Overcoming the Challenges of Symmetry Reveals New Insights into Herpesvirus Biology (Cell)

The oncogenic gammaherpesvirus Kaposi sarcoma-associated herpesvirus (KSHV) is globally widespread; infection rates are as high as 80% in parts of sub-Saharan Africa. In this issue of Cell, Gong et al. (2019) describe the high-resolution structure of a critical component of the KSHV virion--the portal vertex.