IJMS, Vol. 20, Pages 4611: Co-Operation between Aneuploidy and Metabolic Changes in Driving Tumorigenesis (International Journal of Molecular Sciences)

Alterations from the normal set of chromosomes are extremely common as cells progress toward tumourigenesis. Similarly, we expect to see disruption of normal cellular metabolism, particularly in the use of glucose. In this review, we discuss the connections between these two processes: how chromosomal aberrations lead to metabolic disruption, and vice versa. Both processes typically result in the production of elevated levels of reactive oxygen species, so we particularly focus on their role in mediating oncogenic changes.