From Catalytic Antibodies to Antibody-Drug Conjugates (Cell Chemical Biology)

In this issue of Cell Chemical Biology, Hwang et al. (2019) describe a rapid, one-step, one-pot, and enzyme-free assembly strategy under mild conditions for site-specific conjugation of small molecules to antibodies. This is a promising platform for dual-warhead antibody-drug conjugates (ADCs) and other multifaceted antibody conjugates.