Structure of the Respiratory Syncytial Virus Polymerase Complex (Cell)

Respiratory syncytial virus (RSV) remains a leading cause of bronchiolitis and hospitalization, especially of infants. Gilman et al. present a 3.2-Å cryo-EM structure of the RSV L polymerase in complex with the P phosphoprotein--components of the core viral replication machinery that represent an attractive target for the development of therapeutic agents.