Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites (Cell)

Lundby et al. used mass-spectrometry-based proteomics to analyze in vivo EGF signaling in lung tissue. They analyzed changes in the EGF-regulated phosphotyrosine interactome and found that cancer mutations in the vicinity of phosphotyrosine sites induce molecular switches that alter protein signaling networks.