Re: Thomas Loubersac, Molière Nguile-Makao, Frédéric Pouliot, Vincent Fradet, Paul Toren. Neutrophil-to-lymphocyte Ratio as a Predictive Marker of Response to Abiraterone Acetate: A Retrospective Analysis of the COU302 Study. Eur Urol Oncol. In press. http://dx.doi.org/10.1016/j.euo.2019.01.009Re: thomas Loubersac, Molière Nguile-Makao, Frédéric Pouliot, Vincent Fradet, Paul Toren. Neutrophil-to-lymphocyte ratio as a predictive marker of response to abiraterone acetate: a retrospective analysis (European Urology Oncology)
We read with great interest the article by Loubersac et al [1]. The authors conclude that for men with asymptomatic metastatic castration-resistant prostate cancer, the baseline neutrophil-to-lymphocyte ratio (NLR) might be able to predict response to abiraterone, but changes in the NLR while on treatment are not sufficient for guiding treatment. We agree that the NLR might be a good biomarker and the results in the present study are concordant with a recent report by Yasui et al [2]. However, there are some points to be discussed.