Polymorphic Immune Mechanisms Regulate Commensal Repertoire (Cell Reports)

The importance of polymorphic genes in shaping commensal repertoire is unclear. Khan et al. use genetically different GF mice transferred with identical microbiotas to show that polymorphism in both innate and adaptive immune mechanisms influence the output microbiomes. These mechanisms are likely to work in concert with non-polymorphic microbiota-controlling mechanisms.