Conquering Radicals with a Sense of Humor (Cell Chemical Biology)

In this issue of Cell Chemical Biology, Vasavda et al. (2019) present data supporting a neuroprotective role for bilirubin, a bioactive product resulting from heme degradation. While the antioxidant capability of bilirubin is well documented, its role in modulating superoxide radical signaling offers new insight into the regulation of neurotransmission and neuronal survival.