In CheckMate 214, a consistent efficacy benefit with nivolumab plus ipilimumab over sunitinib was observed among patients with one, two, three, or four to six International Metastatic Renal Cell Carcinoma Database Consortium risk factors, suggesting that all patients with intermediate- or poor-risk advanced renal cell carcinoma benefit from nivolumab plus ipilimumab, independent of the number of risk factors.