DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression (Cell Reports)

Resnick et al. show that the DUX4-induced histone variants, H3.X and H3.Y, incorporate into the chromatin of DUX4-induced genes, making them more sensitive to subsequent expression. This suggests a mechanism for how the brief expression of DUX4 can establish a memory of its transcriptional network.