Template Activating Factor-I ? Regulates Retroviral Silencing during Reprogramming (Cell Reports)

Bui et al. use replication-defective and persistent Sendai virus (SeVdp)-based vectors to monitor retroviral silencing during reprogramming and find that the silencing occurs earlier than the acquisition of pluripotency. Insertional chromatin immunoprecipitation (iChIP) identifies TAF-I?, a SET/TAF-I isoform predominant in ESCs, as a factor that facilitates retroviral silencing.