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RSS FeedsAbnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice (Cell Reports)

 
 

13 november 2019 03:04:30

 
Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B-/- Mice (Cell Reports)
 


Peixoto et al. show that the onset of behavioral deficits in Shank3B-/- mice occurs during early postnatal development and that these can be ameliorated by reducing the glutamatergic synaptic drive in medial regions of the striatum by the downregulation of PKA activity.


 
191 viewsCategory: Cell Biology
 
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