The eIF2? Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4 (Neuron)

Pathak et al. reports a critical role for the integrated stress response (ISR) in regulating the physiological functions of the mammalian circadian clock. These findings provide a potential link between dysregulated ISR and clock dysfunction in brain diseases.